Genetic architecture underlying <scp>HPPD</scp> ?inhibitor resistance in a Nebraska <scp> <i>Amaranthus tuberculatus</i> </scp> population

BACKGROUND Amaranthus tuberculatus is a problematic weed species in Midwest USA agricultural systems. Inhibitors of 4-hydroxyphenylpyruvate dioxygenase (HPPD) are an important chemistry for management numerous cropping Here, we characterize the genetic architecture underlying HPPD-inhibitor resistance trait A. population (NEB). RESULTS Dose–response studies F1 generation identified as dominant with factor 15.0–21.1 based on dose required 50% growth reduction. Segregation analysis pseudo-F2 determined moderately heritable (H2 = 0.556) and complex. Bulk segregant validation molecular markers two quantitative loci (QTL), one each Scaffold 4 12. CONCLUSIONS Resistance to HPPD inhibitors complex, largely within NEB population. Two large-effect QTL were controlling tuberculatus. This first mapping study herbicide weedy species.